What Is KPV?
KPV is a tripeptide composed of three amino acids: Lysine (K), Proline (P), and Valine (V). It is derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH), a peptide known for its potent anti-inflammatory properties. KPV retains the core anti-inflammatory activity of α-MSH in a much smaller, more stable molecular form, making it an attractive subject for immune modulation and inflammatory disease research.
Mechanism of Action
KPV exerts its anti-inflammatory effects through multiple pathways. It directly inhibits pro-inflammatory cytokines including IL-1β, TNF-α, and IL-6. It also acts on NF-κB signalling — a central pathway in inflammation regulation — reducing its activation and thereby dampening the inflammatory response. Additionally, KPV can enter cells directly and interact with intracellular inflammatory pathways, a relatively rare property for a peptide of its size.
What Research Shows
Preclinical research on KPV has demonstrated significant anti-inflammatory effects in models of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Studies have shown it can reduce intestinal inflammation, promote gut mucosal healing, and modulate the gut immune environment. Research has also explored its potential in skin inflammation and wound healing.
Research Applications
- Inflammatory bowel disease (IBD) research
- Gut mucosal healing and intestinal immunity studies
- Skin inflammation and wound healing research
- Cytokine modulation and immune regulation investigation
- NF-κB pathway research
Freeze-Dried Format
Our KPV 10mg is available in lyophilised (freeze-dried) powder form, ensuring maximum stability and potency for research applications.
Important Disclaimer
This compound is intended strictly for research purposes only. It is not approved for human consumption and is not intended to diagnose, treat, cure, or prevent any disease.
🛒 Shop This Compound
KPV 10mg is available as part of our Metabo GLP-3 Peptide collection at SONOCOUTURE.